{
  "video_id": "reddit_1tqn8ov",
  "channel_slug": "singularity",
  "channel_handle": "r/singularity",
  "title": "Most of reddit badmouths AI, but my experience in medicine:",
  "url": "https://www.reddit.com/r/singularity/comments/1tqn8ov/most_of_reddit_badmouths_ai_but_my_experience_in/",
  "external_url": null,
  "upload_date": "20260529",
  "published_at": "2026-05-29T01:41:44+00:00",
  "transcript": "I am just blown away that people on reddit (though not this sub) tend to really hate AI, but for my day to day work, it can do things like this (to clarify, I knew the answer ahead of time for the most part, and was testing it). This is paid ChatGPT but doesn't cost much. This response is exactly correct, as good or better than I would get asking a dermatopathologist. Hopefully my job will exist in 10 years, probably still exist but different and fewer of us:\n\nLiver and lung lesions. Clinician expected lung mets. No history of melanoma. Morphologically looks like melanoma with gray cytoplasm, pigment and pseudoinclusions. IHC is SOX-10 strong, negative for ttf-1, p40, ck7, ck20. Do I need to do more staining to establish melanoma.\n\nThought for a second\n\nYes. With **metastatic-looking epithelioid/spindled malignant tumor**, **strong SOX10**, **pigment**, and **nuclear pseudoinclusions**, melanoma is very high on the list—but I would usually add at least **one or two more melanocytic markers** before signing it out as metastatic melanoma, especially with **no known melanoma history** and liver/lung lesions.\n\nA practical confirmatory panel:\n\n**Add:**\n\n* **S100** — very sensitive; helps support melanocytic/neural crest lineage.\n* **Melan-A/MART1 and/or HMB45** — more specific melanocytic differentiation.\n* **PRAME** — useful supportive marker for melanoma, especially if diffuse/strong, though not required.\n* **Pan-cytokeratin or AE1/AE3/CAM5.2** — if not already done, to more firmly exclude carcinoma/sarcomatoid carcinoma.\n* Consider **ERG/CD31** only if vasoformative/epithelioid vascular tumor is in the morphologic differential.\n* Consider **INI1/BRG1** only if unusual rhabdoid/undifferentiated differential.\n\nGiven your current stains, **TTF-1 negative/p40 negative/CK7/CK20 negative** argues against usual lung adenocarcinoma/squamous and many GI/pancreatobiliary carcinomas, but it does not fully exclude a weird carcinoma unless a broad keratin is negative. SOX10 can also be positive in some **salivary/myoepithelial tumors, breast metaplastic/basal tumors, schwannian tumors**, and rare others, so melanoma-specific markers help.\n\nIf you get something like:\n\n* **SOX10 strong diffuse**\n* **S100 positive**\n* **Melan-A and/or HMB45 positive**\n* **keratin negative**\n\n…then I would be comfortable with:\n\n>\n\nIf the melanocytic markers are negative except SOX10, I’d be more cautious:\n\n>\n\nPotential sign-out wording:\n\n>\n\nIf this is a small biopsy and you need to conserve tissue for molecular, I’d prioritize **S100 + Melan-A or HMB45 + broad keratin**. PRAME is nice but not essential.\n\n\n\n--- Top Comments ---\n\n\n[130 upvotes] people hating AI for the job disruption are targeting the wrong problem. this is inevitable, sonner or later it will happen, its not about the tech its about politics.\n\n[127 upvotes] I have absolutely no idea what any of this means, but I'll take your word for it. \n\n[35 upvotes] Most of Reddit is comprised inexperienced people that are <30 years old and grew up on Instagram and TikTok. Then there are the bots which outnumber the humans at this point in time. Most of those bots come from China, Russia and India.\n\nReddit is not the place to seek truth.\n\nMake of that what you will.",
  "transcript_chars": 3240,
  "ingested_at": "2026-05-29T13:30:37.505683+00:00",
  "source": "reddit",
  "yt_meta": {
    "score": 164,
    "upvote_ratio": 0.76,
    "num_comments": 147,
    "author": "Tephros83",
    "is_self": true
  }
}